Massachusetts Institute of Technology
Sign in

Human Genetics: Our Past and Our Future

11/15/2005 6:00 PM Museum
David Altshuler, '86, Founding Member, and Director of the Program in Medical and Population Genetics, Broad Institute; Associate Professor, Genetics and Medicine, Harvard Medical School

Description: Will genomics vanquish our most common diseases, or create a society based on vile eugenics _ or both? David Altshuler outlines these possibilities in his informal talk and conversation at the MIT Museum.

Altshuler is a self-described optimist, and sees promise in current genetic research that attempts to pinpoint why some people develop diseases like adult-onset diabetes or schizophrenia. If we can identify the precise mechanisms inside cells that go haywire in individuals with an inherited predisposition to a certain disease, then it may be possible to design drugs much more accurately. "We're searching for a culprit who committed a crime, where the culprit is a mutation in a DNA sequence that made somebody get sick '. And scientists are the detectives -- CGI: Crime Gene Investigators," says Altshuler.

Scientists have a very powerful tool in the human genome sequence, and they are quickly mapping out genes that cause diseases. But the very tools that permit insight into illness may also permit researchers to isolate genes for other human traits. And this has Altshuler musing: "How about hair loss, intelligence, criminality, athletic ability '.Should society regulate the use of genetic information in reproductive choices?" What if insurance companies gain access to individuals' genetic predictors, and use this to determine risk, and rates? "There's no federal legislation to prevent someone from shaking your hand, scraping off DNA, doing a genetic test and not hiring you or refusing to give you insurance," Altshuler points out. Ultimately, he says, it will be in the hands of the public to strike a balance between restricting the use of genetic information, and permitting its application to cure disease.

About the Speaker(s): Clinical endocrinologist and human geneticist David Altshuler is one of the world's leading scientists in the study of human genetic variation and its application to disease, using tools and information from the Human Genome Project. He is a lead investigator in The SNP Consortium and the International HapMap Project, public-private partnerships that have created public maps of human genome sequence variation as a foundation for disease research. Among his discoveries is the finding of a common genetic variant that increases the risk of contracting type 2 diabetes. He received his B.S. in 1986 from MIT; a Ph.D. in 1993 from Harvard University, and an M.D. in 1994 from Harvard Medical School; he completed his internship, residency and clinical fellowship training at Massachusetts General Hospital.

Host(s): Office of the Provost, MIT Museum

Tape #: T20603

Comments (0)

It looks like no one has posted a comment yet. You can be the first!

You need to log in, in order to post comments.

MIT World — special events and lectures

MIT World — special events and lectures

Category: Events | Updated over 2 years ago

December 12, 2011 21:13
All Rights Reserved (What is this?)
Additional Files

4743 times

More from MIT World — special events and lectures

The Evolution of Sex: Rethinking the Rotting Y Chromosome

The Evolution of Sex: Rethinking th...

Added over 6 years ago | 01:21:00 | 4248 views

Cause for War? Assessing the Bush Administration's Case Against Iraq " Part 2

Cause for War? Assessing the Bush A...

Added over 6 years ago | 00:10:32 | 4928 views

Growing Pains - Transitioning to a Sustainable Energy Economy

Growing Pains - Transitioning to a ...

Added over 6 years ago | 01:29:00 | 5199 views

Responses to September 11: The US, Europe, and the Middle East

Responses to September 11: The US, ...

Added over 6 years ago | 01:52:00 | 3987 views

Introduction/Overview of Brain Disorders

Introduction/Overview of Brain Diso...

Added over 6 years ago | 00:25:38 | 6667 views

The Great Climategate Debate

The Great Climategate Debate

Added over 6 years ago | 01:58:00 | 17369 views