Massachusetts Institute of Technology
Sign in | Create Account

Human Genetics: Our Past and Our Future

11/15/2005 6:00 PM Museum
David Altshuler, '86, Founding Member, and Director of the Program in Medical and Population Genetics, Broad Institute; Associate Professor, Genetics and Medicine, Harvard Medical School

Description: Will genomics vanquish our most common diseases, or create a society based on vile eugenics _ or both? David Altshuler outlines these possibilities in his informal talk and conversation at the MIT Museum.

Altshuler is a self-described optimist, and sees promise in current genetic research that attempts to pinpoint why some people develop diseases like adult-onset diabetes or schizophrenia. If we can identify the precise mechanisms inside cells that go haywire in individuals with an inherited predisposition to a certain disease, then it may be possible to design drugs much more accurately. "We're searching for a culprit who committed a crime, where the culprit is a mutation in a DNA sequence that made somebody get sick '. And scientists are the detectives -- CGI: Crime Gene Investigators," says Altshuler.

Scientists have a very powerful tool in the human genome sequence, and they are quickly mapping out genes that cause diseases. But the very tools that permit insight into illness may also permit researchers to isolate genes for other human traits. And this has Altshuler musing: "How about hair loss, intelligence, criminality, athletic ability '.Should society regulate the use of genetic information in reproductive choices?" What if insurance companies gain access to individuals' genetic predictors, and use this to determine risk, and rates? "There's no federal legislation to prevent someone from shaking your hand, scraping off DNA, doing a genetic test and not hiring you or refusing to give you insurance," Altshuler points out. Ultimately, he says, it will be in the hands of the public to strike a balance between restricting the use of genetic information, and permitting its application to cure disease.

About the Speaker(s): Clinical endocrinologist and human geneticist David Altshuler is one of the world's leading scientists in the study of human genetic variation and its application to disease, using tools and information from the Human Genome Project. He is a lead investigator in The SNP Consortium and the International HapMap Project, public-private partnerships that have created public maps of human genome sequence variation as a foundation for disease research. Among his discoveries is the finding of a common genetic variant that increases the risk of contracting type 2 diabetes. He received his B.S. in 1986 from MIT; a Ph.D. in 1993 from Harvard University, and an M.D. in 1994 from Harvard Medical School; he completed his internship, residency and clinical fellowship training at Massachusetts General Hospital.

Host(s): Office of the Provost, MIT Museum

Tape #: T20603

Comments (0)

It looks like no one has posted a comment yet. You can be the first!

You need to log in, in order to post comments. If you don’t have an account yet, sign up now!

MIT World — special events and lectures

MIT World — special events and lectures

Category: Events | Updated 17 days ago

Created
December 12, 2011 21:13
Category
Tags
License
All Rights Reserved (What is this?)
Additional Files


Viewed
1614 times

More from MIT World — special events and lectures

Liberty by Design

Liberty by Design

Added almost 3 years ago | 01:26:00 | 6663 views

Introducing the TR100

Introducing the TR100

Added almost 3 years ago | 00:41:31 | 1580 views

The Automotive Sector: Future Challenges and Opportunities Future Automotive Technology and Fuels: The Options and Their Impacts

The Automotive Sector: Future Chall...

Added almost 3 years ago | 01:16:00 | 1638 views

Biomaterials and How They Will Change our Lives

Biomaterials and How They Will Chan...

Added 3 years ago | 01:04:00 | 2817 views

Transportation Policy: Thinking Globally, Acting Locally and Walking the Talk

Transportation Policy: Thinking Glo...

Added almost 3 years ago | 01:04:00 | 8378 views

A Few Things Learned from Craigslist

A Few Things Learned from Craigslist

Added almost 3 years ago | 01:12:00 | 23307 views